The rising frequency of chronic diseases such as cancer, autoimmune disorders, and infectious diseases necessitates effective immunotherapy and targeted biologics. As a result the global immunology market was worth roughly $74 billion in 2020, and it is predicted to rise to approximately $150 billion by 2027, at a CAGR of over 10%.
Here, the Adv. Immunology 2023 congress plays a critical role in advancing medical science and improving society's health and well-being by bringing new therapies, focusing on improving diagnosis and disease prevention, and understanding the immune system's mechanisms for better patient outcomes and a healthier population.
Immunology research is predicted to expand in the future. The future of medicine is significantly reliant on immunology research, which holds the promise of unlocking novel therapies and treatments for many diseases that currently have limited treatment options.
Dear Colleagues and Friends
It is a great honour and privilege for us to invite you to the Euro-Global Summit on Advances in Clinical and Cellular Immunology, which will be held on September 11 and 12, 2023, in a beautiful place called London, UK. The central theme being "Advances in Immunology; Researching clinical advances, proactive innovations, new digital technologies, and cutting-edge discoveries that benefit patients and healthcare system".
Adv. Immunology 2023 will consist keynote sessions, distinguished speaker talks, poster presentations, young investigator forums, panel discussions, and B2B meetings. All of these components will be organised in a conference-setting. It provides an ideal venue for researchers from all around the world to display their unique work to the scientific community.
Immunology is a rapidly evolving field that is continuously advancing with new developments and breakthroughs. Technological advances hold enormous potential to improve the field of immunology by providing new insights into the immune system's mechanisms and potential new treatments for a range of diseases. As a result, Adv. Immunology 2023 will foster a few technological advances that could help shape immunology in the future: Precision Immunotherapy, Single-Cell Analysis, Artificial Intelligence (AI), Next-Generation Sequencing (NGS), Nanotechnology, 3D Printing, Advanced Imaging Techniques, Synthetic Biology, Microfluidics and Biomaterials.
In this conference, we hope to build a platform for exchanging knowledge and expertise to create a vibrant atmosphere that will inspire new approaches and research directions. We believe that the conference will provide valuable insights, connections, and opportunities for personal and professional growth.
We are delighted to have you join us, and we look forward to the fruitful discussions, engaging debates, and memorable experiences that lie ahead.
I'm looking forward to interacting with all of you at this outstanding conference.
With best regards,
Adv. Immunology 2023
Organizing Committee
Peers Alley Media, Canada
Antiviral Inteli Strat, Canada
University of Saskatchewan, Canada
U.S. Food and Drug Administration, USA
The University of Hong Kong, China
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Obesjtive of Euro-Global Summit on Advances in Clinical and Cellular Immunology
Market Value of Immunology in USA:
Immunology is a rapidly growing field in the United States with a significant market value. According to a report by Zion Market Research, the global immunology market was valued at $74.1 billion in 2017 and is projected to reach $143.3 billion by 2024, growing at a CAGR of around 10.6% between 2018 and 2024. The USA is one of the leading countries in the field of immunology and is expected to contribute significantly to this growth.
The USA is home to many research institutions and universities dedicated to immunology research. The National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA) are some of the most prominent organizations that conduct research in the field of immunology in the USA.
The demand for immunology research is driven by the rising prevalence of chronic diseases such as cancer, autoimmune diseases, and infectious diseases. The development of novel immunotherapies and biologics is also driving the growth of the immunology market in the USA.
In conclusion, the market value of immunology in the USA is significant and is expected to continue to grow in the coming years.
Market Value of Immunology in Europe:
Immunology is a rapidly growing field in Europe with a significant market value. According to a report by Grand View Research, the global immunology market was valued at €57.5 billion in 2019 and is projected to reach €133.5 billion by 2027, growing at a CAGR of 10.8% between 2020 and 2027. Europe is one of the leading regions in the field of immunology and is expected to contribute significantly to this growth.
Europe is home to many research institutions and universities dedicated to immunology research. Some of the prominent organizations conducting research in the field of immunology in Europe include the European Federation of Immunological Societies (EFIS), the European Molecular Biology Organization (EMBO), and the European Society for Immunodeficiencies (ESID).
The demand for immunology research is driven by the rising prevalence of chronic diseases such as cancer, autoimmune diseases, and infectious diseases. The development of novel immunotherapies and biologics is also driving the growth of the immunology market in Europe.
In conclusion, the market value of immunology in Europe is significant and is expected to continue to grow in the coming years.
Market Value of Immunology in Asia:
Immunology is a rapidly growing field in Asia with a significant market value. According to a report by ResearchAndMarkets, the global immunology market was valued at $74.1 billion in 2017 and is projected to reach $143.3 billion by 2024, growing at a CAGR of around 10.6% between 2018 and 2024. Asia is one of the leading regions in the field of immunology and is expected to contribute significantly to this growth.
Asia is home to many research institutions and universities dedicated to immunology research. Some of the prominent organizations conducting research in the field of immunology in Asia include the Chinese Academy of Sciences (CAS), the National Institute of Immunology (NII) in India, and the Japan Society for Immunology.
The demand for immunology research is driven by the rising prevalence of chronic diseases such as cancer, autoimmune diseases, and infectious diseases in Asia. The development of novel immunotherapies and biologics is also driving the growth of the immunology market in Asia.
In conclusion, the market value of immunology in Asia is significant and is expected to continue to grow in the coming years.
Market Value of Immunology in Middle East:
Immunology is a growing field in the Middle East with a significant market value. However, there is limited information available on the specific market value of immunology in the Middle East.
Some of the countries in the Middle East, such as Israel and Saudi Arabia, have made significant investments in the field of immunology research. Israel, for instance, is home to some of the leading biotechnology companies and research institutions focused on immunology. Similarly, Saudi Arabia has invested heavily in building research infrastructure and developing research programs in immunology.
The demand for immunology research in the Middle East is driven by the increasing prevalence of chronic diseases such as cancer, autoimmune diseases, and infectious diseases. Additionally, the Middle East is also home to a large population affected by genetic disorders, which has led to increased interest in developing personalized immunotherapies.
In conclusion, while the specific market value of immunology in the Middle East is not readily available, the region is expected to contribute to the growth of the global immunology market in the coming years.
Market Value of Immunology in Japan:
Immunology is a rapidly growing field in Japan with a significant market value. According to a report by Grand View Research, the global immunology market was valued at JPY 8.21 trillion in 2019 and is projected to reach JPY 19.02 trillion by 2027, growing at a CAGR of 10.8% between 2020 and 2027. Japan is one of the leading countries in the field of immunology in Asia and is expected to contribute significantly to this growth.
Japan is home to many research institutions and universities dedicated to immunology research. Some of the prominent organizations conducting research in the field of immunology in Japan include the Japanese Society for Immunology (JSI), the RIKEN Center for Integrative Medical Sciences, and the Institute of Medical Science at the University of Tokyo.
The demand for immunology research is driven by the rising prevalence of chronic diseases such as cancer, autoimmune diseases, and infectious diseases in Japan. The development of novel immunotherapies and biologics is also driving the growth of the immunology market in Japan.
In conclusion, the market value of immunology in Japan is significant and is expected to continue to grow in the coming years.
Market Value of Immunology in China:
Immunology is a rapidly growing field in China with a significant market value. According to a report by ResearchAndMarkets, the global immunology market was valued at $74.1 billion in 2017 and is projected to reach $143.3 billion by 2024, growing at a CAGR of around 10.6% between 2018 and 2024. China is one of the leading countries in the field of immunology in Asia and is expected to contribute significantly to this growth.
China is home to many research institutions and universities dedicated to immunology research. Some of the prominent organizations conducting research in the field of immunology in China include the Chinese Academy of Sciences (CAS), the Institute of Basic Medical Sciences at Peking Union Medical College, and the Institute of Immunology at Zhejiang University.
The demand for immunology research in China is driven by the increasing prevalence of chronic diseases such as cancer, autoimmune diseases, and infectious diseases. Additionally, the Chinese government has made significant investments in the biotechnology sector and has encouraged the development of innovative immunotherapies and biologics.
In conclusion, the market value of immunology in China is significant and is expected to continue to grow in the coming years.
Immunology Societies in USA:
American Association of Immunologists / American Academy of Allergy, Asthma, and Immunology / Clinical Immunology Society / American College of Allergy, Asthma & Immunology / American Society of Transplantation / American Society for Histocompatibility and Immunogenetics / Society for Immunotherapy of Cancer / International Society for Interferon and Cytokine Research / International Cytokine and Interferon Society / International Society for Cellular Therapy / International Society for Clinical Laboratory Technology / International Society for Extracellular Vesicles / Society for Leukocyte Biology / International Society of Neuroimmunology / International Society for Biological and Environmental Repositories / International Society for Antiviral Research / International Society for Influenza and Other Respiratory Virus Diseases / International Society for Computational Biology / Society for Mucosal Immunology / American Society for Investigative Pathology / American Association of Pharmaceutical Scientists Immunology Focus Group / Society for Natural Immunity / Clinical Immunology Society / Diagnostic Immunology Focus Group / Society for Immunology and Cancer Immunotherapy / The Association of Medical Laboratory Immunologists (AMLI)
Immunology Societies in Europe:
European Federation of Immunological Societies (EFIS) / British Society for Immunology (BSI) / German Society for Immunology (DGfI) / Italian Society of Immunology, Clinical Immunology and Allergology (SIICA) / French Society of Immunology (SFI) / Spanish Society for Immunology (SEI) / Dutch Society for Immunology (NVVI) / Swiss Society for Allergology and Immunology (SSAI) / Turkish Society of Immunology (TSI) / Belgian Immunological Society (BIS) / Irish Society for Immunology (ISI) / Croatian Immunological Society (HID) / Swedish Society for Immunology (SSI) / Norwegian Society for Immunology (NSI) / Danish Society for Immunology (DSI) / Finnish Society for Immunology (FSI) / Polish Society for Immunology (PTI) / Portuguese Society for Immunology (SPI) / Czech Society for Immunology (CSI) / Austrian Society for Allergology and Immunology (ÖGAI) / Hungarian Society for Immunology (MIT) / Estonian Society for Immunology and Allergology (ESIA) / Latvian Immunologists' Association (LIA) / Lithuanian Society for Immunology (LSI) / Ukrainian Society for Immunology and Allergy (USIA)
Immunology Societies in Asia:
Japanese Society for Immunology (JSI) / Korean Association of Immunologists (KAI) / Indian Immunology Society (IIS) / Chinese Society for Immunology (CSI) / Iranian Society for Immunology and Allergy (ISIA) / Israeli Association of Allergy and Clinical Immunology (IAACI) / Singaporean Society for Immunology (SSI) / Hong Kong Society for Immunology (HKSI) / Taiwan Society of Immunology (TSI) / Allergy and Immunology Society of Thailand (AIST) / Philippine Society for Immunology (PSI) / Malaysian Society for Immunology (MSI) / Indonesian Society for Immunology (ISI) / Bangladesh Association of Immunologists (BAI) / Sri Lankan Society for Immunology and Allergy (SLSIA) / Nepal Society for Immunology and Immunopathology (NSII) / Pakistan Society for Immunology (PSI) / Iraqi Society of Immunologists (ISI) / Syrian Society for Immunology (SSI) / Jordanian Society for Immunology (JSI) / Kuwait Society for Immunology (KSI) / Saudi Society for Immunology (SSI) / United Arab Emirates Immunology Group (UAEIG) / Qatar Immunology Group (QIG) / Omani Society for Immunology (OSI)
Immunology Societies in Middle East:
Iranian Society for Immunology and Allergy (ISIA) / Israeli Association of Allergy and Clinical Immunology (IAACI) / Iraqi Society of Immunologists (ISI) / Syrian Society for Immunology (SSI) / Jordanian Society for Immunology (JSI) / Kuwait Society for Immunology (KSI) / Saudi Society for Immunology (SSI) / United Arab Emirates Immunology Group (UAEIG) / Qatar Immunology Group (QIG) / Omani Society for Immunology (OSI) / Bahrain Society for Immunology and Allergy (BSIA) / Lebanese Society of Allergy and Immunology (LSAI) / Yemeni Society of Immunology (YSI) / Libyan Society for Immunology and Allergy (LSIA) / Tunisian Society of Immunology (TSI) / Algerian Society of Immunology (ASI) / Moroccan Society of Immunology (MSI) / Egyptian Society of Immunology (ESI) / Palestinian Society for Immunology and Allergy (PSIA) / Sudanese Society of Immunology (SSI) / Mauritanian Society for Immunology (MSI) / Djibouti Society of Immunology (DSI) / Somalian Society for Immunology (SSI) / Comorian Society of Immunology (CSI) / Gulf Immunology Society (GIS)
List of Global Immunology Universities:
Harvard University / Stanford University / Massachusetts Institute of Technology / University of California-Berkeley / University of California-Los Angeles / California Institute of Technology / University of Chicago / Yale University / Princeton University / University of Pennsylvania / Columbia University / Duke University / University of Michigan-Ann Arbor / Johns Hopkins University / University of Wisconsin-Madison / University of Texas-Austin / University of Washington / Cornell University / Northwestern University / University of California-San Diego / University of California-San Francisco / University of North Carolina-Chapel Hill / University of Colorado-Boulder / University of Minnesota-Twin Cities / University of Illinois-Urbana-Champaign / University of Virginia / University of Pittsburgh / Washington University in St. Louis / University of California-Irvine / University of Maryland-College Park / University of Southern California / Emory University / University of Arizona / University of Iowa / University of Utah / University of Rochester / University of Massachusetts-Amherst / University of Cincinnati / University of Alabama-Birmingham / University of Kansas / University of Oregon / University of Oklahoma / University of South Carolina / University of Nebraska-Lincoln / University of New Mexico / University of Kentucky / Ulane University / University of Delaware / University of Missouri-Columbia / University of Georgia / University of California-Davis / Indiana University-Bloomington / University of Tennessee-Knoxville / Ohio State University / University of Colorado-Colorado Springs / University of South Florida / University of Arkansas / University of Nevada-Las Vegas / University of Houston / Wayne State University / University of North Dakota / University of Nevada-Reno / University of Toledo / Exas Tech University / University of Maine / University of Wyoming / University of Central Florida / University of Rhode Island / University of Louisiana-Lafayette / University of Mississippi / Baylor University / University of Wisconsin-Eau Claire / Louisiana State University / Appalachian State University / University of North Texas / Virginia Commonwealth University / University of Montana / Florida State University / University of Akron / University of North Florida / University of Alaska-Fairbanks / University of Northern Iowa / Kansas State University / Western Carolina University / University of Wisconsin-Green Bay / University of Wisconsin-La Crosse / Eastern Kentucky University / University of West Florida / University of North Carolina-Charlotte / University of West Georgia / University of South Alabama / University of Wisconsin-Oshkosh / University of Maine-Farmington / University of Wisconsin-Stout / Western Kentucky University / University of Wisconsin-Whitewater / University of Southern Mississippi / University of Arkansas-Little Rock / Appalachian State University / Eastern Michigan University / University of Southern Indiana / East Tennessee State University / University of Wisconsin-Parkside / University of North Carolina-Wilmington / University of Wisconsin-Superior
List Global Immunology Companies:
AbbVie / Amgen / Bristol-Myers Squibb / Roche / Pfizer / Johnson & Johnson / Novartis / Merck & Co / Sanofi / GlaxoSmithKline / Eli Lilly and Company / AstraZeneca / Takeda Pharmaceutical Company Limited / Biogen / Regeneron Pharmaceuticals / Genentech / Alexion Pharmaceuticals / Celgene / BioNTech SE / Moderna / Vertex Pharmaceuticals / CSL Limited / Seattle Genetics / Immunomedics / Sarepta Therapeutics / Dynavax / Technologies Corporation / Adaptimmune Therapeutics / Kite Pharma / Spark Therapeutics / Alnylam Pharmaceuticals / Fate Therapeutics / Apellis Pharmaceuticals / EMD Serono / Bavarian Nordic / Neurocrine Biosciences / MacroGenics / Genmab / Acorda Therapeutics / Sangamo Therapeutics / Atara Biotherapeutics / uniQure / Inovio Pharmaceuticals / Tmunity Therapeutics / IGM Biosciences / Alkermes / PTC Therapeutics / Exelixis / AnaptysBio / Aurinia Pharmaceuticals / Mirati Therapeutics / CytomX Therapeutics / Argenx / Portola Pharmaceuticals / Coherus BioSciences / Theravance Biopharma / Turning Point Therapeutics / Nektar Therapeutics / TG Therapeutics / Miragen Therapeutics / Arrowhead Pharmaceuticals / MyoKardia / Kodiak Sciences / Epizyme / Acceleron Pharma / CRISPR Therapeutics / BioMarin Pharmaceutical / BeiGene / uniQure / Orchard Therapeutics / Akcea Therapeutics / Aimmune Therapeutics / Prothena Biosciences / Aprea Therapeutics / Zymeworks / TCR² Therapeutics / Principia Biopharma / Replimune / Fate Therapeutics / Ocular Therapeutix / Scholar Rock / Karyopharm Therapeutics / Translate Bio / Iovance Biotherapeutics / Trillium Therapeutics / Rubius Therapeutics / Adaptimmune Therapeutics / Inmune Bio / Xencor / X4 Pharmaceuticals / Gritstone Oncology / Surface Oncology / Gossamer Bio / Odonate Therapeutics / Adicet Bio / Orchard Therapeutics / Bellerophon Therapeutics / SpringWorks Therapeutics / Jounce Therapeutics / Aligos Therapeutics / Zentalis Pharmaceuticals
50 Techniques Commonly Used in Immunology Research:
ELISA (Enzyme-Linked Immunosorbent Assay) / Flow cytometry / Western blotting / Immunohistochemistry / Immunofluorescence microscopy / Immunoprecipitation / Tissue culture / Cell sorting / Polymerase chain reaction(PCR) / Microarray analysis / Mass cytometry / RNA sequencing (RNA-seq) / Chromatin immunoprecipitation (ChIP) / In vivo imaging / Immunoelectrophoresis / Transgenic animal models / Knockout animal models / In vitro assays / Cytokine assays / Proteomics / Epigenetic analysis / Retroviral transduction / Lentiviral transduction / CRISPR/Cas9 gene editing / RNA interference (RNAi) / Histology / Animal imaging / Gene expression analysis / High-throughput screening / Surface plasmon resonance (SPR) / X-ray crystallography / Nuclear magnetic resonance (NMR) spectroscopy / Dynamic light scattering (DLS) / Electron microscopy / Immunomagnetic separation / Protein purification / Bacterial and viral challenge assays / Pathogen detection assays / Multiplex assays / Single-cell sequencing / Antibody production and purification / In situ hybridization / Lipidomics / Glycomics / In silico modeling / Imaging mass spectrometry / Metabolomics / Microscopy-based assays / Protease assays / Multiphoton microscopy
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Allergic reactions in neurosurgical procedures are uncommon, but they are detrimental to a patient’s prognosis and recovery. By synthesizing data collected from other surgical fields, possible triggers and alternatives have been identified. Current treatment guidelines involve stabilizing the patient in emergency situations, symptom management, and identification of causative allergens. Preoperative allergy screening is uncommon due to the low prevalence of perioperative hypersensitivity reactions. However, preoperative questionnaire screening can identify when preoperative allergy screening, premedication, or use of a material alternative is necessary. Greater emphasis on material alternatives, increased preoperative screening, and more data can improve the prognosis of neurosurgical patients at risk of perioperative allergic complications.
BACKGROUND: Approximately 5% of advanced stage breast cancer (BC) patients will develop incurable leptomeningeal disease (LMD). One reason for poor prognoses is the issue of drug accessibility to tumor sites due to the blood brain barrier (BBB) and blood-cerebral spinal fluid (CSF)-barrier. While the Ommaya reservoir is used clinically to overcome this challenge, there has not been an optimized preclinical model that allows researchers to adequately test novel therapies in the CSF space. Here, we examined the intrathecal (IT) delivery of peptide-pulsed DC immunotherapies in HER2+ and TNBC BC-LMD in immunocompetent animal models. METHODS: We developed an MRI-compatible device called the “murine Ommaya” which mimics the Ommaya reservoir and allows repeated IT administration directly into CSF, bypassing BBB. In a joint effort with Dr. Czerniecki, whose lab have developed a pipeline for screening immunogenic MHC class II peptides from tumor-associated oncodrivers and subsequently generating tumor-targeting DCs. We have created a platform to IT deliver peptide-pulsed (HER2- and HER3-peptides) DC immunotherapy directly targeting BC-LMD. BC-LMD mice were randomized into following groups: 1) HER2-DC IT 2) HER3-DC IT 3) HER2/HER3-DC IT. Efficacy evaluation and functional analysis were performed. RESULTS AND DISCUSSION: We created a platform to IT deliver peptide-pulsed DC immunotherapy directly targeting BC-LMD. The median survival of untreated BC-LMD was 15 days. All cohorts given IT immunotherapies have prolonged survival (p<0.001). Interestingly, HER2/HER3-DC IT was able to rescue disease mice (71% in HER2+ and 28% in TNBC-LMD) and showed complete tumor regression. Some surviving mice were immune to subsequent tumor rechallenge. In mice CSF, we found evidence of T-cells infiltration, and a robust IFN-? and IL18 response upon treatment. CONCLUSIONS: Our preclinical data supported a clinical trial (approved) of the IT delivery of peptide-pulsed DC in BC patients with LMD.
The evolutionary pressure for life transitioning from extended periods of hypoxia to an increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical pathways supporting the robust life currently present on the planet. First, we discuss how fermentative glycolysis, a primitive metabolic pathway present at the emergence of life, is instrumental for the rapid growth of cancer, regenerating tissues, immune cells but also bacteria and viruses during infections. The ‘Warburg effect’, activated via Myc and HIF-1 respectively in response to growth factors and hypoxia, is an essential metabolic and energetic pathway which satisfies nutritional and energetic demands required for rapid genome replication. Second, we present the key role of lactic acid, the end-product of fermentative glycolysis able to move across cell membranes in both directions via monocarboxylate transporting proteins (i.e. MCT1/4) contributing to cell-pH homeostasis but also to the complex immune response via acidosis of the tumour microenvironment. Importantly lactate is recycled in multiple organs as a major metabolic precursor of gluconeogenesis and energy source protecting cells and animals from harsh nutritional or oxygen restrictions. Third, we revisit the Warburg effect via CRISPR-Cas9 disruption of glucose-6-phosphate isomerase (GPI-KO) or lactate dehydrogenases (LDHA/B-DKO) in two aggressive tumours (melanoma B16-F10, human Colorectal adenocarcinoma LS174T). Full suppression of lactic acid production reduces but does not suppress tumour growth due to reactivation of OXPHOS. In contrast, disruption of the lactic acid transporters MCT1/4 suppressed glycolysis, mTORC1, and tumour growth as a result of intracellular acidosis. Finally, we will briefly discuss the current clinical developments of an MCT1 specific drug AZ3965, and the recent progress for a specific in vivo MCT4 inhibitor, two drugs of very high potential for future clinical applications against cancers, bacterial and viral pathogens.